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J Mol Biol. 2002 Nov 22;324(2):359-71.

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding.

Author information

1
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.

Abstract

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

PMID:
12441113
[Indexed for MEDLINE]

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