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Int J Obes Relat Metab Disord. 2002 Nov;26(11):1465-8.

Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants.

Author information

1
Clinical Toxicology Laboratory, University Hospital, Liege, Belgium. c.charlier@chu.ulg.ac.be

Abstract

BACKGROUND:

Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the hormonal system (endocrine disrupters).

DESIGN:

Thirty obese individuals recruited for gastroplasty were compared before and after treatment with 45 normal-weight people.

MEASUREMENTS:

Blood samples were analyzed for DDT, DDE, HCB and PCBs no. 28, 52, 101, 118, 138, 153 and 180, by gas chromatography-mass spectrometry.

RESULTS:

The results indicate clearly that body weight loss occurring after gastroplasty increases plasma concentration of lipophilic pollutants.

CONCLUSION:

Gastroplasty increases plasma concentration of organochlorine pesticides and PCBs, which could be a risk factor of endocrine disruption. Future longitudinal research will have to determine if the advantages of body weight loss are reduced by this potentially harmful effect.

PMID:
12439648
DOI:
10.1038/sj.ijo.0802144
[Indexed for MEDLINE]

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