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Sex Transm Dis. 2002 Nov;29(11):637-42.

Prevalence of herpes simplex virus type 2 antibody in Cameroon.

Author information

1
Institute of Medical Microbiology and Immunology, University of Bonn, Germany. Anna-Marie.Eis-Huebinger@ukb.uni-bonn.de

Abstract

BACKGROUND:

Genital herpes is one of the most common sexually transmitted diseases. As a leading cause of genital ulceration, herpes genitalis plays a role in facilitating the transmission of HIV. Although HIV infection is most prevalent in Cameroon, information is lacking about prevalence of herpes simplex virus (HSV) type 2 infection in this country.

GOAL:

The goal was to determine the prevalence of HSV-2-specific antibody in blood specimens from individuals in Cameroon.

STUDY DESIGN:

Blood specimens were randomly collected from 410 clinic attendees (215 males, 195 females) in Douala, the most populous city in Cameroon. One hundred fifteen of the individuals (28.0%) were HIV-infected. Samples were tested by a type-common HSV IgG enzyme immunoassay not discriminating between HSV-1 and HSV-2 antibodies and by two glycoprotein G-2-based enzyme immunoassays for detection of HSV-2-specific antibody.

RESULTS:

All but three blood samples were positive for type-common HSV IgG antibodies. Sixty-seven specimens (16.3%) were concordantly negative for HSV-2 antibody by both assays, and 287 (70.0%) specimens were concordantly positive. Fifty-six specimens (13.7%) yielded discrepant results between the two assays.

CONCLUSION:

On the basis of specimens with concordantly positive results, the overall HSV-2 seroprevalence was 70.0%. HSV-2 seroprevalence was significantly higher among HIV-infected individuals than among HIV-negative ones. Because of the serious morbidity and mortality caused by HSV-2, effective programs are needed to halt the spread of HSV-2 infection in Cameroon.

[Indexed for MEDLINE]

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