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J Clin Invest. 2002 Nov;110(10):1441-8.

Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ.

Author information

1
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. mtmslc@gwumc.edu

Abstract

Antigen exposure via airway epithelia is often associated with a failure to prime or with the preferential priming of Th2 cells. We previously reported that the intranasal delivery of a Th1-inducing antigen promoted Th2-dominated responses, rather than the expected Th1 responses. Thus, we proposed that when pulmonary T cell priming is induced, the lung microenvironment might intrinsically favor the generation of Th2 types of responses. To establish a potential mechanism for such preferential priming, we examined the initial interactions between antigens and resident antigen-presenting cells (APCs) within the lung. We show that intranasally delivered antigens are preferentially taken up and can be presented to antigen-specific T cells by a resident population of CD11c(bright) APCs. Most of these antigen-loaded APCs remained within lung tissues, and migration into secondary lymphoid organs was not crucial for T cell priming to occur within the pulmonary tract. Furthermore, these pulmonary APCs demonstrated a marked expression of IL-6 and IL-10 within hours of antigen uptake, suggesting that resident tissue APCs have the capacity to promote Th2 T cell differentiation in situ.

PMID:
12438442
PMCID:
PMC151814
DOI:
10.1172/JCI16109
[Indexed for MEDLINE]
Free PMC Article

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