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J Am Coll Surg. 2002 Nov;195(5):641-7.

Liver resection for hilar cholangiocarcinoma: in-hospital mortality and longterm survival.

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1
Department of Surgical Oncology, Istituto per la Ricerca e la Cura del Cancro, Candiolo, TO, Italy.

Abstract

BACKGROUND:

Extended surgical procedures are the only chance of longterm survival for patients with Klatskin tumors, but high mortality rates have been reported. The type of treatment for Bismuth type l-II carcinomas is still a matter of discussion.

STUDY DESIGN:

We performed a single-unit, retrospective study analyzing 36 patients who underwent resectional surgery for Klatskin tumor.

RESULTS:

An associated liver resection was performed in 88.9% of our patients; most of them had a major hepatectomy. The in-hospital mortality rate was 2.8%. Three- and 5-year survival rates were 40.8% and 27.2%, respectively. But the group of patients with Bismuth type I-II carcinomas undergoing hepatectomy had markedly better longterm outcomes than those undergoing hilar resection (p = 0.04): 54.5% versus 0% at 5 years, respectively; none of the patients who had only resection of bile duct confluence were alive at 2 years. Lymph node metastases were found in 38.8% of our patients; nodal involvement was not a major prognostic factor.

CONCLUSIONS:

Achievement of low in-hospital mortality rates is possible in specialized surgical departments. Aggressive surgical approaches can allow better longterm results in the subset of Bismuth type I-II carcinomas.

PMID:
12437251
[Indexed for MEDLINE]
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