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Biol Chem. 2002 Jul-Aug;383(7-8):1035-44.

Apoptotic pathways: involvement of lysosomal proteases.

Author information

  • 1Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia.

Abstract

Apoptosis or programmed cell death is the major mechanism used by multicellular organisms to remove infected, excessive and potentially dangerous cells. Cysteine proteases from the caspase family play a crucial role in the process. However, there is increasing evidence that lysosomal proteases are also involved in apoptosis. In this review various lysosomal proteases and their potential contribution to propagation of apoptosis are discussed.

PMID:
12437086
DOI:
10.1515/BC.2002.112
[PubMed - indexed for MEDLINE]
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