Superior safety of reboxetine over amitryptiline in the elderly

Eur J Med Res. 2002 Sep 30;7(9):415-6.

Abstract

Under antidepressive treatment with amitryptiline (100 mg/d) a 71-year old woman developed delirious symptoms, hyponatremia and a grand mal seizure followed by cardiovascular arrest. A few month later she ingested 48 mg reboxetine with suicidal intent. Overdosing of reboxetine, a selective noradrenaline re-uptake inhibitor, proceeded without complications.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Aged
  • Amitriptyline / adverse effects*
  • Amitriptyline / therapeutic use
  • Antidepressive Agents / therapeutic use*
  • Antidepressive Agents, Tricyclic / adverse effects*
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Female
  • Humans
  • Morpholines / therapeutic use*
  • Reboxetine
  • Suicide, Attempted / psychology*

Substances

  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Morpholines
  • Amitriptyline
  • Reboxetine