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Curr Opin Genet Dev. 2002 Dec;12(6):675-82.

Human demographic history: refining the recent African origin model.

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Computational and Molecular Population Genetics (CMPG) Lab, Zoological Institute, University of Bern, Baltzerstrasse 6, 3012, Bern, Switzerland.


Recent studies of large portions of the human genome support a recent origin of modern humans from an African stock after a bottleneck of moderate size followed by a range expansion out of Africa. Under this simple scenario, patterns of molecular diversity suggest that balancing selection could be more prevalent than positive selection in coding regions.

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