Format

Send to

Choose Destination
See comment in PubMed Commons below
Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:129-52.

The structures of prostaglandin endoperoxide H synthases-1 and -2.

Author information

1
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing 48824, USA. garavito@msu.edu

Abstract

Despite the marked differences in their physiological roles, the structures and catalytic functions of the prostaglandin H2 endoperoxide synthases-1 and -2 (PGHS-1 and -2) are almost completely identical. These integral membrane proteins catalyze the conversion of arachidonic acid to PGG2 and finally to PGH2. The crystal structures of PGHS-1 and -2 provide new insights into the catalytic mechanism for fatty acid oxygenation. Moreover, a clearer picture emerges to explain how a handful of amino acid substitutions can give rise to subtle differences in ligand binding between the two isoforms. These "small" alterations of isozyme structure are sufficient to allow the design of new, isoform-selective drugs.

PMID:
12432914
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center