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Int J Antimicrob Agents. 2002 Nov;20(5):384-6.

The comparison of in the vitro effect of imipenem or meropenem combined with ciprofloxacin or levofloxacin against multidrug-resistant Pseudomonas aeruginosa strains.

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Clinic of Infectious Disease and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, No: 153/4, 81150 Baglarbasi, Istanbul, Turkey.


This study evaluated the in vitro effects of the combination of a carbapenem (imipenem or meropenem) with a quinolone (ciprofloxacin or levofloxacin) using a microbroth dilution chequerboard technique and multidrug-resistant Pseudomonas aeruginosa strains. The ciprofloxacin and meropenem combination was only synergistic against 2 strains (6.2%) and ciprofloxacin and imipenem against 1 strain (3.1%). Levofloxacin and imipenem or meropenem were not synergistic for against any strain. None of the combinations showed an antagonistic effect.

[Indexed for MEDLINE]

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