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Neuropsychopharmacology. 2002 Nov;27(5):869-73.

Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor.

Author information

1
W. M. Keck Foundation Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, CA 94143, USA. mgf@phy.ucsf.edu

Abstract

Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an enhanced response to sleep deprivation compared with wild-type control mice. These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin.

PMID:
12431861
PMCID:
PMC2452994
DOI:
10.1016/S0893-133X(02)00353-6
[Indexed for MEDLINE]
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