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Trends Endocrinol Metab. 2002 Dec;13(10):444-51.

Role of Akt/protein kinase B in metabolism.

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1
Dept Medicine and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Blvd, 322 Clinical Research Building, Philadelphia, PA 19104, USA.

Abstract

Since its discovery more than a decade ago, the Ser/Thr kinase Akt/PKB (protein kinase B) has been recognized as being remarkably well conserved across a broad range of species and involved in a diverse array of cellular processes. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in several physiologically important target tissues. Refining our understanding of those pivotal molecular components that normally coordinate insulin action throughout the body is essential for a full understanding of insulin resistance in diabetes mellitus and ultimately the successful treatment of this disease.

PMID:
12431841
DOI:
10.1016/s1043-2760(02)00662-8
[Indexed for MEDLINE]

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