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Arch Otolaryngol Head Neck Surg. 2002 Nov;128(11):1292-4.

Correlation of presentation and pathologic condition in primary ciliary dyskinesia.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, University of Southern California Keck School of Medicine, Los Angeles, USA.

Abstract

OBJECTIVES:

To better characterize primary ciliary dyskinesia (PCD) and improve the diagnosis of this uncommon disorder.

STUDY DESIGN AND SETTING:

We retrospectively reviewed the records of 118 patients with ciliary biopsy or brushing specimens examined at Yale University School of Medicine from 1991 to 2001.

RESULTS:

Sinonasal, middle ear, and pulmonary infections were more common in patients with PCD-positive biopsy results than in those with negative results. In addition, PCD caused by random ciliary orientation presented similarly to PCD caused by other ultrastructural defects.

CONCLUSIONS:

Patients who present with cough alone are highly unlikely to have PCD (chi(2 ) test, 24.85; P<.001). In contrast, patients who present with multiple manifestations are highly likely to have PCD (chi(2) test, 22.2; P<.001). This information may assist the clinician in the diagnosis of PCD.

PMID:
12431173
DOI:
10.1001/archotol.128.11.1292
[Indexed for MEDLINE]

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