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J Agric Food Chem. 2002 Nov 20;50(24):6989-92.

Antifungal constituents of the essential oil fraction of Artemisia dracunculus L. Var. dracunculus.

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Agricultural Research Service, U.S. Department of Agriculture, Natural Product Utilization Research Unit, University Of Mississippi, University, Mississippi 38677, USA.


The isolation and structure elucidation of antifungal constituents of the steam-distilled essential oil fraction of Artemisia dracunculus are described. Antifungal activities of 5-phenyl-1,3-pentadiyne and capillarin against Colletrotichum fragariae, Colletrotichum gloeosporioides, and Colletrotichum acutatum are reported for the first time. The relative abundance of 5-phenyl-1,3-pentadiyne is about 11% of the steam-distilled oil, as determined by GC-MS. Methyleugenol was also isolated and identified as an antifungal constituent of the oil.

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