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Arch Ophthalmol. 2002 Nov;120(11):1559-65.

Infantile cataract in the collaborative perinatal project: prevalence and risk factors.

Author information

1
Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bldg 31, Room 6A52, 31 Center Dr, MSC 2510, Bethesda, MD 20892-2510, USA. jpsangio@nei.nih.gov

Abstract

OBJECTIVES:

To estimate the prevalence of 4 categories of infantile cataract in subjects surviving the neonatal period in a US cohort, and to investigate risk factors for isolated infantile cataract.

DESIGN:

Prospective study of 55 908 pregnancies enrolled in the Collaborative Perinatal Project from 1959 to 1965 at 12 university medical centers.

METHODS:

We gathered data on demographic, lifestyle, and prenatal and perinatal obstetrical and postnatal factors using a standardized protocol. Pediatricians and neurologists examined infants at birth, 4 months, 1 year, and 7 years. We used exact logistic regression methods to compare putative risk factors in infants with isolated cataract with those in infants with no history of cataract.

OUTCOME MEASURES:

Infantile cataract as diagnosed using a standardized dilated ophthalmic examination.

RESULTS:

Infantile cataract occurred in 13.6 per 10 000 infants (95% confidence interval [CI], 10.7-17.1). Isolated infantile cataract occurred 3.8 times as often among infants born at weights at or below 2500 g than among those born at or above 2500 g (95% CI, 1.5-8.6; P<.001), after controlling for a set of covariates; we observed similar results for bilateral isolated cataract (odds ratio = 4.4; 95% CI, 1.2-13.9). No risk factor identified in bivariate analyses was independently associated with the odds of developing isolated unilateral infantile cataract.

CONCLUSIONS:

Infantile cataract is a rare disorder occurring during childhood. Prevalence estimates reported here are within the limits of those from large-cohort studies in economically developed nations. Infants born at weights at or below 2500 g have a 3- to 4-fold increased odds of developing infantile cataract.

PMID:
12427072
DOI:
10.1001/archopht.120.11.1559
[Indexed for MEDLINE]

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