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Nat Neurosci. 2002 Dec;5(12):1271-8.

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat.

Author information

1
Department of Anatomy, University of Texas Medical Branch, Galveston, Texas 77555, USA. piwu@utmb.edu

Abstract

Pluripotent or multipotent stem cells isolated from human embryos or adult central nervous system (CNS) may provide new neurons to ameliorate neural disorders. A major obstacle, however, is that the majority of such cells do not differentiate into neurons when grafted into non-neurogenic areas of the adult CNS. Here we report a new in vitro priming procedure that generates a nearly pure population of neurons from fetal human neural stem cells (hNSCs) transplanted into adult rat CNS. Furthermore, the grafted cells differentiated by acquiring a cholinergic phenotype in a region-specific manner. This technology may advance stem cell-based therapy to replace lost neurons in neural injury or neurodegenerative disorders.

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PMID:
12426573
DOI:
10.1038/nn974
[Indexed for MEDLINE]

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