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Biochimie. 2002 May-Jun;84(5-6):391-7.

The Tol proteins of Escherichia coli and their involvement in the translocation of group A colicins.

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Unité de Microbiologie et Génétique, UMR5122 CNRS-INSA, Université Lyon-1, bâtiment André-Lwoff, 10, rue Dubois, 69622 Villeurbanne cedex, France.


The Tol proteins are involved in outer membrane stability of Gram-negative bacteria. The TolQRA proteins form a complex in the inner membrane while TolB and Pal interact near the outer membrane. These two complexes are transiently connected by an energy-dependent interaction between Pal and TolA. The Tol proteins have been parasitized by group A colicins for their translocation through the cell envelope. Recent advances in the structure and energetics of the Tol system, as well as the interactions between the N-terminal translocation domain of colicins and the Tol proteins are presented.

[Indexed for MEDLINE]

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