[The mechanisms and effects of panax notoginside and methylprednisolone in a rat model of pulmonary fibrosis]

Zhonghua Jie He He Hu Xi Za Zhi. 2002 Sep;25(9):520-3.
[Article in Chinese]

Abstract

Objective: To study the effects of panax notoginside (PNS) and methylprednisolone (solu-medrol) on the development of pulmonary fibrosis and the possible underlining mechanisms.

Methods: Rats were divided into 3 groups: pulmonary fibrosis group, PNS treated group and solu-medrol treated group. On days 1, 3, 7, 14, and 28 after bleomycin treatment, 5 rats in each group were killed and the lungs and plasma were harvested for histopathological studies, immunohistochemical determination of collagen I and III and ELISA detection of MIP-1alpha and MCP-1.

Results: The degrees of fibrosis, the levels of collagen I and III, and the levels of MIP-1alpha and MCP-1 decreased significantly in the PNS and solu-medrol treated groups as compared with the fibrosis group (P < 0.05).

Conclusion: Both PNS and solu-medrol are effective in modulating the process of pulmonary fibrosis induced by bleomycin in rats.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Chemokine CCL2 / blood
  • Chemokine CCL3
  • Chemokine CCL4
  • Collagen / biosynthesis
  • Disease Models, Animal
  • Hydroxyproline / analysis
  • Lung / pathology
  • Macrophage Inflammatory Proteins / blood
  • Male
  • Methylprednisolone / therapeutic use*
  • Panax*
  • Phytotherapy*
  • Pulmonary Fibrosis / drug therapy*
  • Pulmonary Fibrosis / metabolism
  • Pulmonary Fibrosis / pathology
  • Rats
  • Rats, Wistar

Substances

  • Chemokine CCL2
  • Chemokine CCL3
  • Chemokine CCL4
  • Macrophage Inflammatory Proteins
  • Collagen
  • Hydroxyproline
  • Methylprednisolone