Format

Send to

Choose Destination
Trends Mol Med. 2002 Nov;8(11):537-42.

Genetically-modified-animal models for human infections: the Listeria paradigm.

Author information

1
Dept of Molecular Biology and Pharmacology, Washington University School of Medicine Campus Box 8103, 660 So. Euclid Ave, St Louis, MO 63110, USA. mlecuit@passteur.fr

Abstract

Several human pathogens exhibit a restricted host-tropism, relying on the species-specific interaction of microbial ligand(s) with host receptor(s). This specificity accounts for some of the difficulties in modeling human infections in animals. The discovery of L. monocytogenes host-specificity and elucidation of the underlying mechanism has led to the generation of transgenic mice expressing one of its human receptors, E-cadherin. This model is presented here as a paradigm of a genetically-modified-animal model for studying a human infectious disease.

PMID:
12421688
DOI:
10.1016/s1471-4914(02)02413-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center