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Carcinogenesis. 2002 Nov;23(11):1777-80.

Migrating colonic crypt epithelial cells: primary targets for transformation.

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Strang Cancer Research Laboratory at the Rockerfeller University, 1230 York Avenue, New York, NY 10021, USA.


It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.

[Indexed for MEDLINE]

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