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Carcinogenesis. 2002 Nov;23(11):1777-80.

Migrating colonic crypt epithelial cells: primary targets for transformation.

Author information

1
Strang Cancer Research Laboratory at the Rockerfeller University, 1230 York Avenue, New York, NY 10021, USA. lampres@mail.rockefeller.edu

Abstract

It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.

PMID:
12419824
[Indexed for MEDLINE]

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