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J Magn Reson. 2002 Sep-Oct;158(1-2):178-82.

3D MR microscopy with resolution 3.7 microm by 3.3 microm by 3.3 microm.

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Department of Physics, Ohio State University, 2030 Smith Labs, 174 West 18th Avenue, Columbus, OH 43210-1016, USA.


The technique of magnetic resonance imaging microscopy holds promise of bringing the full capabilities of NMR to arbitrarily specified positions within spatially inhomogeneous systems, including biological cells, yet the possibilities are limited by the need for adequate sensitivity and spatial resolution. We report proton magnetic resonance images obtained by combining advances in receiver coil sensitivity, gradient strength, and pulse/gradient sequence design. We achieve resolution of 3.7 +/- 0.4 microm by 3.3 +/- 0.3 microm by 3.3 +/- 0.3 microm for a volume resolution approximately 40 femtoliters (corresponding to approximately 3 x 10(12) proton spins).

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