Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3417-9.

6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S.

Author information

1
SynPhar Laboratories, currently NAEJA Pharmaceutical Inc., Edmonton, Alberta, Canada.

Abstract

The synthesis of a new series of 6-acylamino penam derivatives and their inhibition of cysteine proteases cathepsins B, L, K, and S is described. The 6-acylamino-penam sulfone compounds showed excellent cathepsin L, K, and S inhibition activity with IC(50) values in the nanomolar and subnanomolar range.

PMID:
12419374
DOI:
10.1016/s0960-894x(02)00766-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center