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Bioorg Med Chem Lett. 2002 Dec 2;12(23):3363-6.

Chemical modification of reveromycin A and its biological activities.

Author information

1
Synthetic Organic Chemistry Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan. tshimizu@postman.riken.go.jp

Abstract

Various derivatives of reveromycin A, a novel inhibitor of eukaryotic cell growth, were prepared and their inhibitory effects on both isoleucyl-tRNA synthetase activity and in vitro protein synthesis, and activities on the morphological reversion of src(ts)-NRK cells were assayed. The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities.

PMID:
12419362
DOI:
10.1016/s0960-894x(02)00782-5
[Indexed for MEDLINE]

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