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Curr Biol. 2002 Oct 29;12(21):R738-40.

Telomeres: the molecular events driving end-to-end fusions.

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1
Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. abertuch@bcm.tmc.edu

Abstract

Recent data indicate that loss of the protective telomeric capping function leads to active degradation of the telomeric G-strand overhang and DNA ligase IV-mediated non-homologous end joining. These molecular events may contribute to genomic instability early in tumorigenesis.

PMID:
12419205
[Indexed for MEDLINE]
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