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Curr Biol. 2002 Oct 29;12(21):R725-7.

Immunoglobulin genes: generating diversity with AID and UNG.

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1
Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.

Abstract

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.

PMID:
12419200
DOI:
10.1016/s0960-9822(02)01247-2
[Indexed for MEDLINE]
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