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Trends Plant Sci. 2002 Nov;7(11):505-11.

The plant E2F-Rb pathway and epigenetic control.

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Institut de Biologie Moléculaire des Plantes (IBMP), CNRS-ULP, 12 rue du Général Zimmer, 67084 Strasbourg, France.


Plants and animals use the E2F-Rb pathway as a major mechanism of control in the decision to continue or stop cell division. The E2F-Rb pathway controls the G1-to-S-phase transition by the timely activation of genes involved in DNA synthesis and cell-cycle control. Recent findings reveal that the E2F-Rb pathway communicates with chromatin-remodelling factors in the control of transcription and cell-cycle progression. This article highlights the fast-moving advances in the molecular and functional characterization of plant E2F proteins, and in our understanding of how the E2F-Rb pathway is activated and repressed.

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