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Trends Plant Sci. 2002 Nov;7(11):487-91.

DICER-LIKE1: blind men and elephants in Arabidopsis development.

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Dept of Biology, University of Rochester, NY 14627, USA.


Genetic studies of embryo, ovule and flower development in Arabidopsis thaliana have led to the independent isolation of different mutant alleles of a single gene (SIN1/SUS1/CAF, now renamed DCL1) that encodes a complex RNA-processing enzyme. DCL1 shows similarity to the Dicer group of genes, which are required for RNA silencing in Drosophila and Caenorhabditis. These recent findings identify a novel but conserved mechanism of post-transcriptional gene regulation that is important for development in eukaryotes.

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