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J Clin Psychiatry. 2002 Oct;63(10):910-1.

Serum bupropion levels in 2 breastfeeding mother-infant pairs.

Author information

1
Frances Payne Bolton School of Nursing, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

Abstract

BACKGROUND:

These are the first reported data on bupropion and hydroxybupropion levels in infants whose treated mothers were breastfeeding. The information will assist physicians and parents in the risk-benefit decision-making process for bupropion treatment during breastfeeding.

METHOD:

Serum samples were obtained by venipuncture from 2 mother-infant pairs. The serum was assayed for levels of bupropion and its most active metabolite, hydroxybupropion.

RESULTS:

Neither infant had quantifiable serum levels of bupropion or its metabolite at steady state. Neither infant had medical problems during the time of maternal therapy.

CONCLUSION:

We recommend obtaining and publishing additional serum level findings for breastfeeding mother-infant pairs since data for bupropion are favorable but limited.

PMID:
12416600
DOI:
10.4088/jcp.v63n1008
[Indexed for MEDLINE]

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