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J Rheumatol. 2002 Nov;29(11):2407-9.

Active ingredient consistency of commercially available glucosamine sulfate products.

Author information

1
Faculties of Pharmacy and Medicine, University of Alberta, Edmonton, Alberta, Canada.

Abstract

OBJECTIVE:

To assess the content of active ingredient in over-the-counter (OTC) glucosamine sulfate (GLS) preparations.

METHODS:

We analyzed in a coded, blind manner 14 commercially available capsules or tablets of GLS, plus one herbal mixture as a control. We used a high performance liquid chromatography system as described.

RESULTS:

The amount of free base varied from 41 to 108% of the mg content stated on the label; the amount of glucosamine varied from 59 to 138% even when expressed as sulfate.

CONCLUSION:

If GLS is used as a therapeutic agent, it is important that the products conform to a standard in their description. The content is probably best expressed in terms of free base.

PMID:
12415601
[Indexed for MEDLINE]

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