Abstract
In a current publications, it has been suggested that hypoxia-triggered "good angiogenesis" involving hypoxic up-regulation of vascular endothelial growth factor (VEGF) molecules, genes, and receptors is likely responsible in a major way for the remarkable gut and patient salvage experience associated with use of the "patch, drain, and wait" (PD&W) surgical approach to perforated necrotizing enterocolitis and midgut volvulus (MGV) with extensive ischemia/necrosis. We report a case in which extensive ischemia/necrosis in a newborn with gastroschisis (likely MGV-induced) was managed successfully by PD&W with an associated marked (24-fold) elevation of VEGF in drainage fluid at 7 days post-initiation of PD&W.
MeSH terms
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Body Fluids / chemistry*
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Digestive System Surgical Procedures*
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Drainage*
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Endothelial Growth Factors / analysis*
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Endothelial Growth Factors / physiology
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Enterocolitis, Necrotizing / complications
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Enterocolitis, Necrotizing / physiopathology
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Enterocolitis, Necrotizing / surgery*
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Humans
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Infant, Newborn
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Infant, Premature
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Infant, Premature, Diseases / surgery*
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Intercellular Signaling Peptides and Proteins / analysis*
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Intercellular Signaling Peptides and Proteins / physiology
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Intestinal Obstruction / physiopathology
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Intestinal Obstruction / surgery
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Intestinal Perforation / etiology
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Intestinal Perforation / physiopathology
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Intestinal Perforation / surgery
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Lymphokines / analysis*
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Lymphokines / physiology
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Male
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Neovascularization, Physiologic
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Peritoneal Cavity
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Surgical Mesh
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
Substances
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Endothelial Growth Factors
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Intercellular Signaling Peptides and Proteins
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Lymphokines
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors