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Nat Rev Immunol. 2002 Nov;2(11):888-97.

A positive look at double-negative thymocytes.

Author information

1
U548 INSERM, CEA-G, 17 rue des Martyrs, F-38054 Grenoble, France. ceredig@dsvsud.cea.fr

Abstract

In some respects, our understanding of the cellular and molecular aspects of early T-cell differentiation is lagging behind that of B cells. Papers describing gene-knockout and reporter-transgenic mice in which thymocyte development is affected are often difficult to interpret. Progress in this field will be hampered unless a more detailed phenotypic and molecular analysis of progenitor thymocytes at the single-cell level is carried out.

PMID:
12415312
DOI:
10.1038/nri937
[Indexed for MEDLINE]
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