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Nat Rev Immunol. 2002 Nov;2(11):859-71.

Stem cell medicine encounters the immune system.

Author information

1
Department of Surgery, Cambridge University Clinical School, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. jab@cam.ac.uk

Abstract

Recent progress in deriving human embryonic stem (hES) cells and defining their capacity to differentiate has inspired hope that they could become a source of replacement cells for damaged or diseased tissues. We review the immunological barriers to transplanting hES cells and consider several potential solutions, including stem-cell banking, modification of the immunogenicity of donor cells and induction of tolerance to the graft. We evaluate the probable efficacy of these approaches with a view to facilitating the use of hES cells in clinical practice.

PMID:
12415309
DOI:
10.1038/nri934
[Indexed for MEDLINE]
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