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Lancet. 2002 Oct 26;360(9342):1302-4.

Compulsions, Parkinson's disease, and stimulation.

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CNRS UMR 7593 and Service de Psychiatrie, Pavillon Clérambault, GH Pitié-Salpêtrière, Hôpital de la Salpêtrière, Assistance Publique-Hôpital de Paris, 75651 Cedex 13, Paris, France.


Pathophysiological models suggest that obsessive compulsive disorder (OCD) might be associated with dysfunctions in cortico-striato-pallido-thalamo-cortical neuronal circuits. We implanted subthalamic electrodes to alleviate parkinsonian symptoms in two patients who had Parkinson's disease and a history of severe OCD. Parkinsonian disability improved postoperatively in both patients, and 2 weeks after the procedure, their compulsions had disappeared and obsessive symptoms improved (58% improvement for patient 1 on the Yale-Brown obsessive compulsive scale, 64% for patient 2). The improvements in these two patients suggest that high-frequency stimulation could improve function in the subcortical-limbic circuitry in patients with severe OCD.

[Indexed for MEDLINE]

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