Format

Send to

Choose Destination
Fertil Steril. 2002 Nov;78(5):1068-72.

Minimal ovarian hyperstimulation for in vitro fertilization using sequential clomiphene citrate and gonadotropin with or without the addition of a gonadotropin-releasing hormone antagonist.

Author information

1
Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA. williasc@evms.edu

Abstract

OBJECTIVE:

To compare the results of a minimal-stimulation protocol with those of a standard protocol used for IVF.

DESIGN:

Retrospective, controlled study.

SETTING:

University center.

PATIENT(S):

Fifty-five patients undergoing IVF using a minimal-stimulation protocol with or without adjuvant therapy with a GnRH antagonist. A control group consisted of age- and diagnosis-matched patients undergoing a standard long GnRH agonist (GnRH-a)-gonadotropin stimulation during the same time period.

INTERVENTION(S):

Clomiphene citrate and gonadotropins, with or without the GnRH antagonist ganirelix.

MAIN OUTCOME MEASURE(S):

Oocytes recovered and pregnancy rates.

RESULT(S):

The number of oocytes retrieved was significantly lower for the minimal-stimulation regimen compared with the case of the long GnRH-a protocol (4.8 +/- 2.6 vs. 16.2 +/- 7.5, respectively). The clinical pregnancy rate per transfer, however, was not significantly different between the two regimens (37% vs. 41%, minimal stimulation vs. long GnRH-a protocol, respectively). The addition of ganirelix resulted in at least the same pregnancy outcome as compared with the case of cycles without the antagonist.

CONCLUSION(S):

Minimal stimulation using clomiphene citrate followed by gonadotropin for IVF results in pregnancy rates equal to the standard long GnRH-a-gonadotropin protocol. The addition of ganirelix resulted in at least similar results with the advantage of eliminating the occurrence of a premature endogenous LH surge.

PMID:
12413995
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center