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Curr Opin Chem Biol. 2002 Oct;6(5):676-81.

Imaging mass spectrometry: a new tool to investigate the spatial organization of peptides and proteins in mammalian tissue sections.

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Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University, Nashville, TN 37232-6400, USA.


MALDI MS imaging mass spectrometry can be used to map the distribution of targeted compounds in tissue sections with a spatial resolution currently of about 50 microm, providing important molecular information in many areas of biological research. After matrix application, a raster of a section by the laser beam yields ions from compounds in a tissue mass-to-charge range from 1000 to over 100000. Two-dimensional intensity maps can then be reconstructed to provide specific molecular images of a tissue.

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