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Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Sep;36(5):291-4.

[The microarray study on the stress gene transcription profile in human retina pigment epithelial cells exposed to microwave radiation].

[Article in Chinese]

Author information

  • 1Department of Pathology, The First Military Medical University, Guangzhou 510515, China.

Abstract

OBJECTIVE:

To study the difference in stress and apoptosis related genes transcription between hTERT-RPE1 cells exposed to simulated microwave radiation and the cells with heat water bath, and the effects of microwave on gene transcription in cultured human retina pigment epithelial cells.

METHODS:

cDNA microarray technique was used to detect the mRNA isolated from hTERT-RPE1 cells exposed to 2 450 MHz simulated microwave radiation and with heat water bath, respectively.

RESULTS:

Among the 97 related aim genes, there were seven genes up-regulating its transcription, i.e., M31166 (2.52fold), L24123 (2.66fold), AF039704 (2.22fold), U67156 (2.07fold), AF040958 (2.13fold), NM-001423 (2.63fold) and NM-005346 (3.68fold). But, no notably down-regulating gene in transcription was detected.

CONCLUSIONS:

Microwave could induce up-regulating in multiple stress and apoptosis related genes transcription in cultured human retina pigment epithelial cells, hTERT-RPE1 cells. Microwave radiation has unique effect itself in addition to its heat effect.

PMID:
12411184
[PubMed - indexed for MEDLINE]
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