Expression of the costimulatory molecule BB-1 and its receptors in patients with scleroderma-polymyositis overlap syndrome

J Neurol Sci. 2002 Dec 15;205(1):65-70. doi: 10.1016/s0022-510x(02)00309-x.

Abstract

We investigated expression of costimulatory molecules BB-1, B7-1 (CD80), B7-2 (CD86), and their counter-receptors CD28 and CTLA-4 (CD152) in muscle biopsy specimens of patients with scleroderma-polymyositis overlap syndrome (SSc-PM), primary polymyositis (PM), and other related diseases to examine whether the muscle fibers in patients with SSc-PM behave as antigen-presenting cells (APCs). The major histocompatibility (MHC) class II-positive muscle fibers of SSc-PM patients reacted with monoclonal antibodies (mAb) against BB-1 but not against B7-1 or B7-2. The CD4+ T cells expressed the counter-receptors CD28 and CTLA-4, and bound with the BB-1-positive muscle fibers in cell-to-cell contact. Our findings show that muscle fibers in patients with SSc-PM function as "professional" APCs in a way distinct from muscle fibers in patients with primary PM.

MeSH terms

  • Abatacept
  • Adult
  • Aged
  • Antigens, CD
  • Antigens, Differentiation / genetics
  • Antigens, Differentiation / metabolism
  • Antigens, Differentiation, B-Lymphocyte / genetics
  • Antigens, Differentiation, B-Lymphocyte / metabolism
  • B7-1 Antigen / genetics
  • B7-1 Antigen / metabolism*
  • Bacterial Proteins / metabolism
  • Biopsy
  • CD28 Antigens / genetics
  • CD28 Antigens / metabolism*
  • CD4 Antigens / genetics
  • CD4 Antigens / immunology
  • CD8 Antigens / genetics
  • CD8 Antigens / metabolism
  • CTLA-4 Antigen
  • Female
  • Histocompatibility Antigens Class II / genetics
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Immunoconjugates*
  • Immunohistochemistry
  • Middle Aged
  • Polymyositis / complications
  • Polymyositis / genetics
  • Polymyositis / metabolism*
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Scleroderma, Systemic / complications
  • Scleroderma, Systemic / genetics
  • Scleroderma, Systemic / metabolism*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Antigens, Differentiation, B-Lymphocyte
  • B7-1 Antigen
  • Bacterial Proteins
  • CD28 Antigens
  • CD4 Antigens
  • CD8 Antigens
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Histocompatibility Antigens Class II
  • Immunoconjugates
  • Map protein, Staphylococcus aureus
  • RNA, Messenger
  • invariant chain
  • Abatacept