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RETRACTED ARTICLE

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Cell. 2002 Oct 18;111(2):265-80.

Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin.

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1
Department of Genetics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

Erratum in

  • Cell. 2003 Jul 25;114(2):267.

Abstract

Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at the cell surface to transcriptional regulation by TCF in the nucleus. The consensus view is that Wnt signaling induces beta-catenin to enter the nucleus and combine with TCF to form a transcription factor complex in which TCF binds DNA and the C-terminal domain of beta-catenin activates transcription. Here, we present findings, which challenge this view and suggest instead that beta-catenin may transduce Wnt signals by exporting TCF from the nucleus or activating it in the cytoplasm.

PMID:
12408870
DOI:
10.1016/s0092-8674(02)01037-1
[Indexed for MEDLINE]
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