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Cell. 2002 Oct 18;111(2):159-62.

A chromosome RNAissance.

Author information

1
Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720, USA. afdernburg@lbl.gov

Abstract

In RNA-mediated interference (RNAi), double-stranded RNAs (dsRNAs) target complementary mRNAs for degradation. New work demonstrates that essential chromosomal functions are mediated through RNAi protein components and short RNAs, which alter chromosome function at specific DNA loci via histone modification.

PMID:
12408860
DOI:
10.1016/s0092-8674(02)01039-5
[Indexed for MEDLINE]
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