Format

Send to

Choose Destination
Cell. 2002 Oct 18;111(2):147-50.

Dueling activities of AIF in cell death versus survival: DNA binding and redox activity.

Author information

1
Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA. slipton@burnham.org

Abstract

Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.

PMID:
12408857
DOI:
10.1016/s0092-8674(02)01046-2
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center