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Cell. 2002 Oct 18;111(2):143-6.

Endocytosis: driving membranes around the bend.

Author information

1
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. james.hurley@nih.gov

Abstract

When a nascent vesicle buds, the membrane must curve. Several mechanisms have been proposed for curvature creation or stabilization. Structural analysis of the ENTH domain of the endocytic protein epsin has suggested a new mechanism, in which the ENTH domain pushes its way into membranes, thus bending them into shape.

PMID:
12408856
DOI:
10.1016/s0092-8674(02)01044-9
[Indexed for MEDLINE]
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