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Neuron. 2002 Oct 24;36(3):345-8.

Nogo on the go.

Author information

1
Département de Pathologie et biologie cellulaire, Université de Montréal, 2900 Edouard-Montpetit, Montreal, Quebec, H3T 1J4, Canada. mckerral@patho.umontreal.ca

Abstract

Growth inhibition in the central nervous system (CNS) is a major barrier to axon regeneration. Recent findings indicate that three distinct myelin proteins, myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte-myelin glycoprotein (OMgp), inhibit axon growth by binding a common receptor, the Nogo66 receptor (NgR), and likely converge on a common signaling cascade.

PMID:
12408839
[Indexed for MEDLINE]
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