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Dev Cell. 2002 Oct;3(4):465-7.

The (theoretical) yin and yang of spindle mechanics.

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1
Max Planck Institute of Cell Biology and Genetics, Dresden, Germany.

Abstract

Antiparallel overlap of microtubules is central to the morphogenesis of bipolar mitotic spindles. How does this overlap arise, and how is it maintained? A recent theoretical study uses computer simulations to investigate whether motor protein complexes can achieve this task. The "virtual" results reveal that a mixed polarity motor complex is needed to do the job.

PMID:
12408797
DOI:
10.1016/s1534-5807(02)00294-0
[Indexed for MEDLINE]
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