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Nat Immunol. 2002 Nov;3(11):1006-12.

Viral evasion of natural killer cells.

Author information

1
Department of Molecular and Cellular Biology, Harvard University, Cambridge MA, USA.

Abstract

Viruses have evolved mechanisms to avoid the host immune system, including means of escaping detection by both the innate and adaptive immune responses. Natural killer (NK) cells are a central component of the innate immune system and are crucial in defense against certain viruses. To attain a state of chronic infection, some successful viruses have developed specific mechanisms to evade detection by and activation of NK cells. These NK cell-specific evasion mechanisms fall into distinct mechanistic categories used in numerous virus families.

PMID:
12407408
DOI:
10.1038/ni1102-1006
[Indexed for MEDLINE]

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