Format

Send to

Choose Destination
See comment in PubMed Commons below
Hum Psychopharmacol. 2001 Jan;16(1):45-52.

Phospholipid metabolism and depression: the possible roles of phospholipase A2 and coenzyme A-independent transacylase.

Author information

1
Laxdale Research, Kings Park House, Laurelhill Business Park, Stirling, Scotland FK7 9JQ, UK.

Abstract

Phospholipids make up 60 per cent of the dry weight of the brain. They are essential for neuronal and especially for synaptic structure and play key roles in the signal transduction responses to dopamine, serotonin, glutamate and acetyl choline. The unsaturated fatty acid components of phospholipids are abnormal in depression, with deficits of eicosapentaenoic acid and other omega-3 fatty acids and excesses of the omega-6 fatty acid arachidonic acid. Correction of this abnormality by treatment with eicosapentaenoic acid improves depression. The fatty acid abnormalities provide a rational explanation for the associations of depression with cardiovascular disease, immunological activation, cancer, diabetic complications and osteoporosis. The abnormalities cannot be explained by diet, although diet may attenuate or exacerbate their consequences. A number of enzyme abnormalities could explain the phenomena: phospholipase A(2), and coenzyme A-independent transacylase are strong candidates.

PMID:
12404597
DOI:
10.1002/hup.182
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center