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Psychopharmacology (Berl). 2002 Nov;164(2):233-5. Epub 2002 Sep 13.

Rosmarinic acid and caffeic acid reduce the defensive freezing behavior of mice exposed to conditioned fear stress.

Author information

1
Department of Pharmacology and Intractable Diseases Research Center (Division of Drug Research and Development), Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan. ht0417@tokyo-med.ac.jp

Abstract

RATIONALE:

We previously showed that rosmarinic acid from the leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba) and its major metabolite caffeic acid have antidepressive-like activity in the forced swimming test.

OBJECTIVE:

The present study was designed to examine whether rosmarinic acid and caffeic acid might also be effective in other types of stress model.

METHODS:

The conditioned fear stress paradigm was used as a stress model for assessing the effects of rosmarinic acid and caffeic acid.

RESULTS:

Rosmarinic acid (0.25-4 mg/kg, IP) induced a dose-dependent, U-shaped reduction in the duration of the defensive freezing behavior of mice exposed to conditioned fear stress. Caffeic acid (1-8 mg/kg, IP) also dose-dependently reduced this freezing behavior. However, neither substance, at doses that produced a significant reduction in the freezing behavior, affected spontaneous motor activity.

CONCLUSIONS:

These results confirm that rosmarinic acid and caffeic acid may inhibit the emotional abnormality produced by stress.

PMID:
12404088
DOI:
10.1007/s00213-002-1253-5
[Indexed for MEDLINE]

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