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Nat Neurosci. 2002 Nov;5 Suppl:1058-61.

Neuroprotective and neurorestorative strategies for Parkinson's disease.

Author information

1
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. tdawson@jhmi.edu

Abstract

Advances in understanding the molecular mechanisms of cell death and the pathogenesis of sporadic and familial Parkinson's disease are creating new opportunities for the development of neuroprotective and/or neurorestorative therapies. Here we review many of these advances, highlighting areas and strategies that might be particularly suited to the development of innovative approaches that prevent degeneration and/or restore function in Parkinson's disease.

PMID:
12403986
DOI:
10.1038/nn941
[Indexed for MEDLINE]

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