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Nat Rev Drug Discov. 2002 Aug;1(8):621-36.

Drugs targeting the renin-angiotensin-aldosterone system.

Author information

1
Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. amin.zaman@ccc.uab.edu

Abstract

Effective antihypertensive therapy has made a major contribution to the reductions in the morbidity and mortality of cardiovascular disease that have been achieved since the 1960s. However, blood-pressure control with conventional drugs has not succeeded in reducing cardiovascular disease risks to levels seen in normotensive persons. Drugs that inhibit or antagonize components of the renin-angiotensin-aldosterone system are addressing this deficiency by targeting both blood pressure and related structural and functional abnormalities of the heart and blood vessels, thus preventing target-organ damage and related cardiovascular events.

PMID:
12402502
DOI:
10.1038/nrd873
[Indexed for MEDLINE]
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