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Cytokine Growth Factor Rev. 2002 Dec;13(6):429-39.

Regulation of lymphoid homeostasis by interleukin-15.

Author information

1
Department of Medicine, Ben May Institute for Cancer Research, University of Chicago, 5841 S Maryland Ave MC 6084, Chicago, IL 60637, USA.

Abstract

Interleukin (IL)-15 is a member of the common gamma chain family of cytokines, and is closely related to IL-2. While these two cytokines share several important biological functions in vitro, recent mouse models have demonstrated unique roles for these two cytokines in supporting lymphoid homeostasis in vivo. IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis.

PMID:
12401478
DOI:
10.1016/s1359-6101(02)00029-1
[Indexed for MEDLINE]

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