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Science. 2002 Oct 25;298(5594):830-4.

Timing requirements for insulin/IGF-1 signaling in C. elegans.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0448, USA.

Abstract

The insulin/IGF-1 (where IGF-1 is insulin-like growth factor-1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We find that in Caenorhabditis elegans, the pathway acts during adulthood, to relatively advanced ages, to influence aging. In contrast, it regulates diapause during development. In addition, the pathway controls longevity and reproduction independently of one another. Together our findings show that life-span regulation can be dissociated temporally from phenotypes that might seem to decrease the quality of life.

PMID:
12399591
DOI:
10.1126/science.1074240
[Indexed for MEDLINE]
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